Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
but the rate of growth appeared to slow noticeably in a number of top cities.
位于芬兰赫尔辛基的开发商Remedy Entertainment通过之前的作品《英雄本色》（Max Payne）和《心灵杀手》（Alan Wake）模糊了好莱坞和游戏之间的界限。如今，这家工作室将次世代的图像技术与紧张气氛和电视剧剧本结合了起来。故事设置在Riverport大学城，玩家将控制杰克o乔伊斯和贝斯o怀尔德。这两人原本是普通人，但在一次导致时间裂缝的意外中，他们获得了操纵时间的超能力。在游戏过程中，时间体系会随时崩溃，导致环境中的时间暂停、断续、倒流和冻结。玩家在游戏中会与帝王联盟（Monarch Corporation）展开对抗，喜欢《英雄本色》中子弹时刻的玩家，可以在放大时间因素的枪战中寻找新的战略。除了虚拟的故事情节，游戏还采用了定制的实景真人叙事模式，根据玩家的不同选择将产生不同的后果。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The Lego Batman Movie
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Total Program Cost: $118,000
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Yes. Mr Modi’s overnight ban on using high-value bank notes was a big shock, and seriously disrupted the economy. But it delivered rich political rewards, bolstering the premier’s image as a decisive leader willing to take tough action against corruption. With the next general elections due in 2019, Mr Modi will be tempted to deliver one more big bang to dazzle voters. Watch out for dramatic action against wealthy individuals holding properties in others’ names to hide their ownership.
Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.
Trends and targets in antiviral phototherapy
The Cems masters in management, the international programme provided through a network of 30 business schools, is ninth, down five places from 2015, when it was last ranked.
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
US schools are rebuilding their strength in this ranking, with their number increasing to 51. This had dropped below 50 for the first time in 2016, down to 47. Six of the eight new or returning schools are from the US.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
ACE2 as a potential therapeutic target for pandemic COVID-19
At a Senate committee hearing on extrajudicial executions in the Philippines, Ronald Dela Rosa said 712 people had been killed in police anti-narcotics operations since July 1, the day after Mr Duterte assumed the presidency, while 1,067 deaths were being investigated as drug-related vigilante killings.
这些新数据是由一个叫做全球碳计划(Global Carbon Project)的追踪项目提交的，发表在了期刊《自然·地球科学》(Nature Geoscience)上。数据公布之际，正是联合国(United Nations)一次峰会召开前夕。此次峰会意在激发新的政治愿望来解决气候变化问题。科学家说，这些数据表明，如果要把长期的全球变暖问题控制在可以承受的范围内，还需要做出极大的努力。
Diagnostic technologies for COVID-19: a review
It is the eighth straight year that the metropolis has led Chinese cities in terms of consumer spending.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
'A little bit in shock,' said director Steve McQueen, before shrugging 'Roll, Jordan, roll'-the lyrics to the old gospel song sung in the slavery epic.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
China has been making progress in terms of prevention and control of AIDS, said Wang Bin, an NHC official in charge of disease prevention, during the press conference.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
会。梅亚德是执政党革命制度党(PRI)的候选人。他主要的竞争对手是强硬的左翼领导人安德烈斯曼努埃尔洛佩斯奥夫拉多尔(Andrés Manuel López Obrador)——可以感召人群的激情演说家。梅亚德需要克服很多问题：在去年1月一夜间把油价上调20%、引发通胀飙升后，他必须说服选民自己仍然是可以信任的。他还必须证明自己是个有主见的人，而不仅仅是这届不受欢迎的政府的傀儡——在遏制猖獗的腐败和犯罪行为方面，这届政府极为失败。但是凭借强大的PRI拉票机器，他可能势不可挡。在墨西哥只有一轮选举的体制下，30%的选票可能就足以让他当选总统了。
Antiviral drug discovery: broad-spectrum drugs from nature
The People’s Bank of China has long intervened in foreign-exchange markets to hedge against excessive volatility. Since August, however, such intervention has expanded from the domestic spot market, which covers daily transactions, to include the offshore renminbi market in Hong Kong, as well as both onshore and offshore futures markets, traders say.
根据世界黄金协会(World Gold Council)的数据，自2008年以来全球黄金供应每年都增长，这一增长在去年陷入停滞。作为世界最大的黄金生产国，去年中国的黄金供应创纪录地下降9%，这是自1980年来中国的黄金产出第二次下降。
Influenza neuraminidase: A druggable target for natural products
Professor Kaufmann and a colleague, Gareth Harris, found that white Britons who lived in areas that are rapidly diversifying became more likely to vote for the right-wing British National Party. Daniel Hopkins, a professor of political science at the University of Pennsylvania, found a similar pattern of ethnic change leading to anti-immigrant politics in the United States.
THE AMERICANS (FX, Jan. 28) Season 3 of this terrific blend of Cold War spy thriller and family drama begins with Washington’s K.G.B. contingent feeling the weight of the Soviet war in Afghanistan. Frank Langella joins the cast as the new handler for the show’s husband-and-wife agents, replacing Margo Martindale’s Claudia. (Making its premiere eight days later: NBC’s “Allegiance,” about Russian spies embedded in the United States. Huh.)
Both the film and the television series are adapted from the Taiwan action role-playing game of the same name which was developed by Softstar Entertainment. The game is considered by many as simply one of the best Chinese RPG's ever created.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
'We are quite confident that it should sell towards the high end of the estimate or above.'
Mr Draghi hit back the day after the December vote, saying that there was no “limit” to what eurozone policymakers could do to return inflation to its target.
The role of biosensors in the detection of emerging infectious diseases
Before that, she starred in popular sitcom, and has also made a name for herself in films.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
'He does smoke cigarettes, he smokes many, many cigarettes.
6. You dressed 10 times nicer than usual yesterday。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
I'm only a child yet I know if all the money spent on war was spent on ending poverty and finding environmental answers, what a wonderful place this earth would be! 我只是一个小孩，然而我知道，要是把花在战争上的钱，用在找寻环境问题答案上来，或用在结束贫穷并找到解决的方案上来，这个星球将是个多么美好的地方啊！
Inhibition of SARS coronavirus helicase by bismuth complexes
The letter surfaced in a Pennsylvanian university mailroom earlier this month.
If you have been out of work for a long time, it may be time to consider taking a job you wouldn't have looked at before.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
And – oh, right – ethics. "You're not being fair to your employer if you're using the company's dime to get the heck out of there," Foss says。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
"Investing in improving innovation quality is essential for closing the innovation divide," said Soumitra Dutta, dean of Cornell College of Business and co-editor of the report.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
When reflecting on the year in film, moviegoers often remember strong performances, or they might consider how a movie worked as a narrative, the emotions it evoked, what chances it took.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
On 2 March, the North's state-run website Uriminzokkiri warned that Pyongyang would respond to any balloon launches with "not just a few shots of gunfire but cannons or missiles".
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Morgan Slain, CEO of SplashData said: "Seeing passwords like 'adobe123' and 'photoshop' on this list offers a good reminder not to base your password on the name of the website or application you are accessing.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The wealth and depth of knowledge from around the world adds tremendous value to the course, wrote another graduate from the US, adding that “with so many cultures and experiences represented, a classroom ethics discussion about bribery is not your typical boring USA version”.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Former Disney star-turned-wild child singer Miley Cyrus followed as the number two 'celeb gone good', according to the website. Father-to-be Channing Tatum came in third.
Average age: 36
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
And, at random, some other highlights from the list:
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
The average price for new residential buildings rose 12.3 per cent in October year on year, according to a weighted average from Reuters based on data from the National Bureau of Statistics.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
An investigation is continuing into how La La Land was wrongly named Best Picture rather than the triumphant Moonlight.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
My fellow trainer, Sylvia Guinan, made me aware of these rules that a husband has laid out for his wife to follow during the 2014 World Cup.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
China’s trade surplus grew to Rmb496.2bn last month from Rmb382.1bn in December. Economists expected it to inch higher to Rmb389bn. In dollar terms, China’s trade surplus rose to $63.29bn from $60.09 in December and versus expectations of $60.6bn.
The swap is due largely to the major security breach at software company Adobe in October which affected tens of millions of users.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
4.Sex and the City Caused a Rush on Cupcakes
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
She emotes with some of Pink's husky attitude and some of Sia's theatrical so-over-it-ness, but she's a warmer singer than either, whether shrugging off a lover on the self-explanatory "IDGAF" or matching Miguel's intensity on the steamy "Lost in Your Light."
The number of people holding degrees from colleges or universities reached 170.93m, which means there were 12,445 people with an advanced education per 100,000 people in 2015, up from 8,930 in 2010. The number of people who had attended a senior high school also increased, and the number who had only completed lower-level education fell.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Whether Russia, one of 15 successor states to the USSR, which broke up in 1991, is still a genuine world power in 2015 is open to question.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The term was first devised by psychologist Johan Denollet from Tilburg University who created a quiz to identify a type D personality.
A modular microarray imaging system for highly specific COVID-19 antibody testing
?Bond has it all and that's exactly what the most beautiful women demand in the men they date. Women who really enjoy sex prefer "bad boys" -- and there's no doubt 007 qualifies. Feminine women prefer masculine men. And for one night stands women look for physical attractiveness and dominance -- which Bond has in spades.
Six regions recorded GDP growth less than 7 percent, with China's north-eastern rust belt Liaoning province at the bottom with negative growth.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
这两部纪录片都使用标准工具——资料影像、人物采访，悉心选择的音乐资料——在目前的紧张局势中书写历史。在“黑人的命也是命”(Black Lives Matter)的时代，关于黑豹党和爵士歌手兼行动分子妮娜·西蒙妮的影片确实意义重大。尼尔逊和贾巴斯精彩地讲述了他们的故事。
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
6. You dressed 10 times nicer than usual yesterday。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Belty is great that it uses technology to track fitness, water intake, and posture, but for $395, you might be better off getting the same in a stylish smart watch or activity tracker.
The questions can seem like a sudden reversal after decades of rising multiculturalism, through the civil rights movement in the United States and the European Union’s opening up of borders.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
James Gorman, a Times reporter, accompanied scientists who are trying to understand the genes that distinguish dogs from wolves. Humans who raise wolf puppies must spend 24 hours a day, seven days a week with them in order to socialize these puppies for scientific study. And while the pups may seem cute, they will grow to be predatory wolves, not humanity’s faithful companions. The researchers hope their work will help reveal the trigger that made some ancient wolves into the dogs we know today.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Price growth in top cities was slower, however, with Beijing, for instance, reporting a rise of only 0.5 per cent from the previous month, compared to 4.9 per cent in September.
A facile assay for rapid detection of COVID-19 antibodies
? Heavy snow has fallen in West Virginia, with up to 17 inches in Webster Springs. The National Weather Service has warned that more is on the way.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
My Sunshine is a TV drama adapted from Gu Man`s novel of the same title. It stars Wallace Chuang and Tang Yan, premiering in January, 2015. The drama depicts a man and a woman`s reunion and long-lasting romance after seven years of separation. The novel itself has been popular on the Internet and was published in 2003. Wallace Chuang soon rose to become a romantic icon among female viewers because of the role he played in the adaptation, presenting an ideal image of lover to the audiences.
If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
The FT European Business School Ranking 2016 measures the quality and breadth of schools’ postgraduate programmes. It is based on their performance in the five main rankings published by the Financial Times each year: MBA, Executive MBA (EMBA), Masters in Management (MiM) and the two rankings for executive education. Only schools that take part in all five are eligible for a full score.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
“…was checking his cell phone and chewing gum during the meeting.”
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
WHAT: A Greek Revival with four bedrooms and four and a half bathrooms
2. The Hammocraft
"Shanghai has taken a series of tough measures to curb population growth since 2014, including renovating urban villages and regulating group renting," Zhou Haiwang, an expert with the Shanghai Academy of Social Sciences, told the Global Times.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
High and rising US rates may quickly become drivers of EM crises: such conditions may lead to higher borrowing costs in EMs, along with capital outflows and an unwillingness by the financial sector to take risks.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The Aftermath of Zika Virus
LONDON — In the 1970s, the British comedian Tommy Cooper used to tell a joke about asking an auction house to value a violin and a painting that he had discovered in an attic. The good news, he was told, is that they were made by Stradivarius and Rembrandt. The bad news was that the painting was by Stradivarius and the violin was by Rembrandt.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道，我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动！
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
Russian and English fans may have dominated headlines during this month's Euro 2016 football championships for their boorish, thuggish behavior.
《为奴十二年》导演史蒂夫?麦奎因(Steve McQueen)在登台领奖时说：我有点吓到了。然后他微微耸肩，引用片中福音歌曲的歌词，说了句“翻涌吧，约旦河，翻涌吧”("Roll, Jordan, roll")。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
As for China, lack or stopped development represents the biggest risk for this country. So it is essential that we maintain steady medium-high growth of our economy and that in itself is China’s contribution to global stability.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
Going into the debate at Lynn University in Boca Raton, Florida, Obama had an inbuilt advantage on foreign policy and security. As president, with access to daily briefings by intelligence analysts, diplomats and generals, he is better briefed and it showed as he dominated Romney in the first half of the debate.