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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

but the rate of growth appeared to slow noticeably in a number of top cities.
位于芬兰赫尔辛基的开发商Remedy Entertainment通过之前的作品《英雄本色》(Max Payne)和《心灵杀手》(Alan Wake)模糊了好莱坞和游戏之间的界限。如今,这家工作室将次世代的图像技术与紧张气氛和电视剧剧本结合了起来。故事设置在Riverport大学城,玩家将控制杰克o乔伊斯和贝斯o怀尔德。这两人原本是普通人,但在一次导致时间裂缝的意外中,他们获得了操纵时间的超能力。在游戏过程中,时间体系会随时崩溃,导致环境中的时间暂停、断续、倒流和冻结。玩家在游戏中会与帝王联盟(Monarch Corporation)展开对抗,喜欢《英雄本色》中子弹时刻的玩家,可以在放大时间因素的枪战中寻找新的战略。除了虚拟的故事情节,游戏还采用了定制的实景真人叙事模式,根据玩家的不同选择将产生不同的后果。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

《量子破碎》
扫盲:Illuminati字面意思为“先觉者”,是启蒙运动时期的一个巴伐利亚秘密组织,成立于1776年5月1日。它的成员中包括文学巨匠歌德和哲学家海德这样声名赫赫的人物,但它存在的时间却十分短暂。我们熟知的Illuminati(光明会)最早的首脑,正是大名鼎鼎的伽利略。他非常喜爱对称物,于是另一位光照派成员——艺术大师贝尔尼尼便为伽利略设计了一件杰作。他将16世纪时人们认为组成世界的四大元素:土(earth)、水(water)、火(fire)、气(air)以及Illuminati(光明会)这五个原本并非对称字的单词设计成了对称的文字,即在倒转180度之后与原来的形状一模一样的文字图案。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 定制时代,门窗行业该如何发展?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

The Lego Batman Movie

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

Total Program Cost: $118,000

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

6.Belize
当年秋天开学后,达洛伊西奥开始感觉到肩上背负起了来自投资方的巨大压力。他需要改善软件的运算法则,于是他找到了以色列一个从事自然语言处理的编程团队,并签订了合同。他还用谷歌(Google)搜索找到了一位居住在泰国、在该领域有过重要著作的退休教授。达洛伊西奥说,他成了我们的科研主管,他现在在雅虎的森尼维尔办公室工作。
Yes. Mr Modi’s overnight ban on using high-value bank notes was a big shock, and seriously disrupted the economy. But it delivered rich political rewards, bolstering the premier’s image as a decisive leader willing to take tough action against corruption. With the next general elections due in 2019, Mr Modi will be tempted to deliver one more big bang to dazzle voters. Watch out for dramatic action against wealthy individuals holding properties in others’ names to hide their ownership.
Some 695 million netizens used mobile phones to access the Internet in 2016, with a growth rate exceeding 10 percent for the third straight year, the report said. Smartphone-based Internet use accounted for 95.1 percent of all Internet users, up from 90.1 percent in 2015.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

The Cems masters in management, the international programme provided through a network of 30 business schools, is ninth, down five places from 2015, when it was last ranked.
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.
安联:小奥运会
时间:2011-02-16 编辑:beck

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

当小李子上台领取奖杯时,制片人哈维·韦恩斯坦兴奋地拍拍他的背,全场观众起立为他喝彩。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

US schools are rebuilding their strength in this ranking, with their number increasing to 51. This had dropped below 50 for the first time in 2016, down to 47. Six of the eight new or returning schools are from the US.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

巴黎排行第三,预计接待游客1803万人。
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

At a Senate committee hearing on extrajudicial executions in the Philippines, Ronald Dela Rosa said 712 people had been killed in police anti-narcotics operations since July 1, the day after Mr Duterte assumed the presidency, while 1,067 deaths were being investigated as drug-related vigilante killings.
这些新数据是由一个叫做全球碳计划(Global Carbon Project)的追踪项目提交的,发表在了期刊《自然·地球科学》(Nature Geoscience)上。数据公布之际,正是联合国(United Nations)一次峰会召开前夕。此次峰会意在激发新的政治愿望来解决气候变化问题。科学家说,这些数据表明,如果要把长期的全球变暖问题控制在可以承受的范围内,还需要做出极大的努力。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

It is the eighth straight year that the metropolis has led Chinese cities in terms of consumer spending.
Anne-Sylvaine Chassany

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 湖州城中村改造签约突破3万户
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

近两年P2P贷款行业迅速发展。根据E-Lending House,截至6月底,该行业未清偿贷款达2090亿元人民币。
林怡仲预测道,下半年A股IPO的数量或将维持与上半年相当,预计2016年全年A股IPO为120宗左右,融资规模在600-800亿元人民币左右。
一些科学家说,2014年成为创下气温纪录的一年,最值得注意的一点是该年度并没有发生强大的厄尔尼诺现象,一种由于太平洋将巨大的热量输送到大气层所造成的大尺度天气模式。
Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

'A little bit in shock,' said director Steve McQueen, before shrugging 'Roll, Jordan, roll'-the lyrics to the old gospel song sung in the slavery epic.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

China has been making progress in terms of prevention and control of AIDS, said Wang Bin, an NHC official in charge of disease prevention, during the press conference.
到了明年3月,这些明日之星中很有可能会有1-2个人脱颖而出,可以成为球队基石。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

在一份电邮声明中,国际足联表示,在小组赛中,三等票总计售出143364张,相当于每场比赛就卖出了3000张。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 三四线城市个贷增长明显
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

会。梅亚德是执政党革命制度党(PRI)的候选人。他主要的竞争对手是强硬的左翼领导人安德烈斯曼努埃尔洛佩斯奥夫拉多尔(Andrés Manuel López Obrador)——可以感召人群的激情演说家。梅亚德需要克服很多问题:在去年1月一夜间把油价上调20%、引发通胀飙升后,他必须说服选民自己仍然是可以信任的。他还必须证明自己是个有主见的人,而不仅仅是这届不受欢迎的政府的傀儡——在遏制猖獗的腐败和犯罪行为方面,这届政府极为失败。但是凭借强大的PRI拉票机器,他可能势不可挡。在墨西哥只有一轮选举的体制下,30%的选票可能就足以让他当选总统了。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

这之后,场均进球数一直在下滑。2010年南非世界杯上,这一数目跌至2.27个,仅次于1990年意大利世界杯的2.2个。
adj. 国内的,家庭的,驯养的
The People’s Bank of China has long intervened in foreign-exchange markets to hedge against excessive volatility. Since August, however, such intervention has expanded from the domestic spot market, which covers daily transactions, to include the offshore renminbi market in Hong Kong, as well as both onshore and offshore futures markets, traders say.
根据世界黄金协会(World Gold Council)的数据,自2008年以来全球黄金供应每年都增长,这一增长在去年陷入停滞。作为世界最大的黄金生产国,去年中国的黄金供应创纪录地下降9%,这是自1980年来中国的黄金产出第二次下降。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 藤制家具标准将在2015年制订完成
Review Article

Influenza neuraminidase: A druggable target for natural products

单词brace 联想记忆:
Professor Kaufmann and a colleague, Gareth Harris, found that white Britons who lived in areas that are rapidly diversifying became more likely to vote for the right-wing British National Party. Daniel Hopkins, a professor of political science at the University of Pennsylvania, found a similar pattern of ethnic change leading to anti-immigrant politics in the United States.
THE AMERICANS (FX, Jan. 28) Season 3 of this terrific blend of Cold War spy thriller and family drama begins with Washington’s K.G.B. contingent feeling the weight of the Soviet war in Afghanistan. Frank Langella joins the cast as the new handler for the show’s husband-and-wife agents, replacing Margo Martindale’s Claudia. (Making its premiere eight days later: NBC’s “Allegiance,” about Russian spies embedded in the United States. Huh.)
但崩盘还是来了。经济下滑,衰退持续了30个月,华尔街把我们的退休金拿去亏了超过八万亿美元。从2000年网络股崩盘到2010年的灾难,在21世纪的头10年里,华尔街经通胀因素调整后的绩效为负。今天华尔街的回报率也只是刚刚战胜通货膨胀。难怪投资者觉得被华尔街的赌场骗了。
Both the film and the television series are adapted from the Taiwan action role-playing game of the same name which was developed by Softstar Entertainment. The game is considered by many as simply one of the best Chinese RPG's ever created.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

'We are quite confident that it should sell towards the high end of the estimate or above.'
Mr Draghi hit back the day after the December vote, saying that there was no “limit” to what eurozone policymakers could do to return inflation to its target.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

Before that, she starred in popular sitcom, and has also made a name for herself in films.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

达洛伊西奥设计了一款名叫Summly的应用软件,该软件能够将繁冗的文章精简成几行关键句子。早一代Summly软件发布后,技术观察家意识到在这个无论资讯还是财报,一切新闻都快速阅于掌上的时代,这样一款简洁、精准的摘要软件蕴含着巨大的价值。该应用吸引了包括好莱坞明星和亚洲首富李嘉诚在内的全世界投资者的兴趣。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 西宁市住房公积金政策有调整
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

201001/94005.shtml【英文原文】
萨拉考林斯
第九步 每天,告诉全世界“别BB了”,其实这样蛮圈粉的
2017年,衡量工业品出厂价格、反映经济活力的主要指标--生产者物价指数(PPI)上涨6.3%,结束了自2012年以来的连续下降态势。2016年PPI下降1.4%。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

俄罗斯为世界上第十大经济体,除了天然气(碳氢化合物),经济贡献甚微。腐败和寻租行为使经济蒙受巨大损失。它依然沿用着苏联时代的基础设施,并且满足国民教育、医疗需求的能力正急速下滑。
《飞马》是一部19世纪先驱摄影师埃德沃德.迈布里奇的传记电影,该片是加里.奥德曼近20年来执导的首部电影,也是他人生中的第二部作品。影片聚焦于迈布里奇的妻子芙洛拉以及被他杀害的戏剧评论家哈利.拉金斯之间的绯闻。电影目前尚未确定出演阵容,但奥德曼一直在争取拉尔夫.费因斯以及本尼迪克特.康伯巴奇。奥德曼本人将扮演迈布里奇的检察官。
'He does smoke cigarettes, he smokes many, many cigarettes.
6. You dressed 10 times nicer than usual yesterday。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 家居电商化须探“特色”之路
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

I'm only a child yet I know if all the money spent on war was spent on ending poverty and finding environmental answers, what a wonderful place this earth would be! 我只是一个小孩,然而我知道,要是把花在战争上的钱,用在找寻环境问题答案上来,或用在结束贫穷并找到解决的方案上来,这个星球将是个多么美好的地方啊!
中国互联网金融行业继续保持快速增长的节奏。作为国内最大的个人对个人(P2P)网贷平台,陆金所(Lufax)正在寻求10亿美元的新融资,这将使其估值达到150亿至200亿美元。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

The letter surfaced in a Pennsylvanian university mailroom earlier this month.
If you have been out of work for a long time, it may be time to consider taking a job you wouldn't have looked at before.
这是中国首次占据榜单前三甲以及在前10强中占了5名。中国工商银行连续两年占据第1名的宝座,中国建设银行次之,而且中国农业银行向上移动了5名成为第3名。这三大银行与排在第9名的中国银行一起跻身前10强,中国银行是“四大国有银行”中的另一个成员。
manifest显示,证明+o表名词,“人,物或状态”→宣言,声明
正如英国东安格利亚大学影视高级讲师布霄特?米尔斯所言,《老友记》是首部讲述20来岁年轻人所面临的问题的情景剧。而看剧就像在读一个年轻人的人生故事。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

在这场新闻发布会上,国家卫生健康委员会负责疾病预防的官员王斌称,中国已经在预防和控制艾滋病方面取得了进展。
decision
And – oh, right – ethics. "You're not being fair to your employer if you're using the company's dime to get the heck out of there," Foss says。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

"Investing in improving innovation quality is essential for closing the innovation divide," said Soumitra Dutta, dean of Cornell College of Business and co-editor of the report.
该研究的公布正值美国政界反中国言论日益增加之际,此外,今年夏天3起针对从中国进口的钢铁产品的政治敏感反倾销案件即将作出裁决,可能导致美方对中国企业施加高达500%的惩罚性关税。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

When reflecting on the year in film, moviegoers often remember strong performances, or they might consider how a movie worked as a narrative, the emotions it evoked, what chances it took.
available
怎样减肥?

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

5.电子烟
美联储政策中任何意外举动的潜在影响,在2013年的“缩减恐慌”(taper tantrum)中表露无遗,当时,仅是美联储可能很快缩减其超宽松货币政策力度的暗示就足以引发一波全球恐慌。
On 2 March, the North's state-run website Uriminzokkiri warned that Pyongyang would respond to any balloon launches with "not just a few shots of gunfire but cannons or missiles".

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

“目前市场上有大量尖端,环保的人造皮草,我相信你会同意现在没有任何借口来杀死动物以获取皮草了。”

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

Morgan Slain, CEO of SplashData said: "Seeing passwords like 'adobe123' and 'photoshop' on this list offers a good reminder not to base your password on the name of the website or application you are accessing.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

The wealth and depth of knowledge from around the world adds tremendous value to the course, wrote another graduate from the US, adding that “with so many cultures and experiences represented, a classroom ethics discussion about bribery is not your typical boring USA version”.
玛莎·切利取出嘴里的香烟,喃喃低语:"我也曾经这么想过。"说完便又抽起了烟。马克震惊了(我们想象一下,当知道你的亲生母亲可能会在你沐浴时杀了你,这反应很正常)。马克第一次意识到家庭主妇会变得多么绝望和孤独。接着,他就想到这会是电视剧的一个好素材。这次谈话便开启了《绝望主妇》的制作。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Former Disney star-turned-wild child singer Miley Cyrus followed as the number two 'celeb gone good', according to the website. Father-to-be Channing Tatum came in third.
她笔下的人物们觉得自己为了登上“美国梦”的山巅,经历了漫长的排队等候,但是上山的队伍放慢了速度,甚至停顿下来了。而那些移民、黑人和其他“外来者”似乎还在插队。
Average age: 36
联想首席执行官杨元庆

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

And, at random, some other highlights from the list:
男女学员对所攻读项目的优势评价一样。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

本周四公布的一项最新调查显示,近四成美国居民表示,最近发生的桑迪飓风等自然灾害的严重性正是世界末日即将到来的证据,就像《圣经》中预言的那样。而超过六成的受访者认为这是气候变化所致。
The average price for new residential buildings rose 12.3 per cent in October year on year, according to a weighted average from Reuters based on data from the National Bureau of Statistics.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

An investigation is continuing into how La La Land was wrongly named Best Picture rather than the triumphant Moonlight.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

求职市场很艰难并非意味着找到工作是不可能。Challenger说:“你应该更努力地去找工作。”
My fellow trainer, Sylvia Guinan, made me aware of these rules that a husband has laid out for his wife to follow during the 2014 World Cup.
共和党候选人时常表现出不确定以及偶尔会忘了自己要说的,好像在试图记住他的简要笔记。当奥巴马从一开始就咄咄逼人时他开始出汗,在伊朗、伊拉克、俄罗斯以及美国的军费开支的交流中他才表现得更好。
adj. 概要的,简略的

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

China’s trade surplus grew to Rmb496.2bn last month from Rmb382.1bn in December. Economists expected it to inch higher to Rmb389bn. In dollar terms, China’s trade surplus rose to $63.29bn from $60.09 in December and versus expectations of $60.6bn.
The swap is due largely to the major security breach at software company Adobe in October which affected tens of millions of users.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

黄记泳表示,去年赴韩旅游的中国游客超过800万人,同比增长36%。他还表示,甚至在韩国政府宣布部署萨德之后,该数字也曾继续上升。
4.Sex and the City Caused a Rush on Cupcakes
9.忠诚待人

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

unemployment
She emotes with some of Pink's husky attitude and some of Sia's theatrical so-over-it-ness, but she's a warmer singer than either, whether shrugging off a lover on the self-explanatory "IDGAF" or matching Miguel's intensity on the steamy "Lost in Your Light."
The number of people holding degrees from colleges or universities reached 170.93m, which means there were 12,445 people with an advanced education per 100,000 people in 2015, up from 8,930 in 2010. The number of people who had attended a senior high school also increased, and the number who had only completed lower-level education fell.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
From the themed collection: 2016年是涂料企业最艰难的一年?
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Whether Russia, one of 15 successor states to the USSR, which broke up in 1991, is still a genuine world power in 2015 is open to question.
温莎王朝的非官方座右铭“永不抱怨,永不解释”到底可信不可信?

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 在线短租房 可能让你住的很糟心
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

1月份,沃尔玛美国公司总裁兼首席执行官比尔西蒙承诺,这家全球最大零售企业将在今后五年内聘用10万名老兵。此外,作为美国最大的私营雇主,沃尔玛还表示它将邀请光荣退伍不到一年的老兵加盟公司。
即使我们把吉布森视作租赁合同并且他将在夏天离开,雷霆对这笔交易依然感觉良好。
The term was first devised by psychologist Johan Denollet from Tilburg University who created a quiz to identify a type D personality.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

?Bond has it all and that's exactly what the most beautiful women demand in the men they date. Women who really enjoy sex prefer "bad boys" -- and there's no doubt 007 qualifies. Feminine women prefer masculine men. And for one night stands women look for physical attractiveness and dominance -- which Bond has in spades.
Six regions recorded GDP growth less than 7 percent, with China's north-eastern rust belt Liaoning province at the bottom with negative growth.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

这两部纪录片都使用标准工具——资料影像、人物采访,悉心选择的音乐资料——在目前的紧张局势中书写历史。在“黑人的命也是命”(Black Lives Matter)的时代,关于黑豹党和爵士歌手兼行动分子妮娜·西蒙妮的影片确实意义重大。尼尔逊和贾巴斯精彩地讲述了他们的故事。
charter
v. 拥抱,包含,包围,接受,信奉

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

6. You dressed 10 times nicer than usual yesterday。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

如果2017年是假新闻之年,那么2018年将成为假数据之年。就像假新闻以多种不同形式出现一样——既有被美国总统称为假新闻的真新闻,也有在社交媒体上吸引众多观众的无稽之谈——假数据也是如此。
谎言6:我29岁。说谎原因:29岁听起来比30岁要年轻多了。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
From the themed collection: 长春警方立案调查长生生物
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

The Belty is great that it uses technology to track fitness, water intake, and posture, but for $395, you might be better off getting the same in a stylish smart watch or activity tracker.
The questions can seem like a sudden reversal after decades of rising multiculturalism, through the civil rights movement in the United States and the European Union’s opening up of borders.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

楼下还有一间八边形的小房间,内有筒形穹顶天花板,几面玻璃墙和一条嵌壁式长凳座椅。这个房间配备了环绕立体声。三间卧室都在楼上,全都带有湖景。
James Gorman, a Times reporter, accompanied scientists who are trying to understand the genes that distinguish dogs from wolves. Humans who raise wolf puppies must spend 24 hours a day, seven days a week with them in order to socialize these puppies for scientific study. And while the pups may seem cute, they will grow to be predatory wolves, not humanity’s faithful companions. The researchers hope their work will help reveal the trigger that made some ancient wolves into the dogs we know today.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 高效集约利用土地破解空间难题
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

这家Post-it即时贴和思高(Scotch)胶带制造商在2月份授权进行120亿美元的股票回购,取代当前75亿美元的回购计划。《财富》美国500强公司3M公司(3M) 遵循了去年末发表的声明行动。这项声明称,公司在之后4年准备投入100亿美元用于收购,最多将投入220亿美元用于回购。
Price growth in top cities was slower, however, with Beijing, for instance, reporting a rise of only 0.5 per cent from the previous month, compared to 4.9 per cent in September.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: 上市家居企业“年中预喜”
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

? Heavy snow has fallen in West Virginia, with up to 17 inches in Webster Springs. The National Weather Service has warned that more is on the way.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

My Sunshine is a TV drama adapted from Gu Man`s novel of the same title. It stars Wallace Chuang and Tang Yan, premiering in January, 2015. The drama depicts a man and a woman`s reunion and long-lasting romance after seven years of separation. The novel itself has been popular on the Internet and was published in 2003. Wallace Chuang soon rose to become a romantic icon among female viewers because of the role he played in the adaptation, presenting an ideal image of lover to the audiences.
If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
The FT European Business School Ranking 2016 measures the quality and breadth of schools’ postgraduate programmes. It is based on their performance in the five main rankings published by the Financial Times each year: MBA, Executive MBA (EMBA), Masters in Management (MiM) and the two rankings for executive education. Only schools that take part in all five are eligible for a full score.
统筹城市地上地下建设,再开工建设城市地下综合管廊2000公里以上,启动消除城区重点易涝区段三年行动,推进海绵城市建设,使城市既有“面子”、更有“里子”。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

“…was checking his cell phone and chewing gum during the meeting.”

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

WHAT: A Greek Revival with four bedrooms and four and a half bathrooms
2. The Hammocraft
"Shanghai has taken a series of tough measures to curb population growth since 2014, including renovating urban villages and regulating group renting," Zhou Haiwang, an expert with the Shanghai Academy of Social Sciences, told the Global Times.

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

《王冠》
High and rising US rates may quickly become drivers of EM crises: such conditions may lead to higher borrowing costs in EMs, along with capital outflows and an unwillingness by the financial sector to take risks.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

The Aftermath of Zika Virus
LONDON — In the 1970s, the British comedian Tommy Cooper used to tell a joke about asking an auction house to value a violin and a painting that he had discovered in an attic. The good news, he was told, is that they were made by Stradivarius and Rembrandt. The bad news was that the painting was by Stradivarius and the violin was by Rembrandt.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道,我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动!

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

4. 蕾哈娜
1.Nepal
内森说:“如今,你必须根据行情购买。不过,如果你很大胆,不跟随潮流,那么你也有很多机会。”

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

arrogant
elite
Russian and English fans may have dominated headlines during this month's Euro 2016 football championships for their boorish, thuggish behavior.
《为奴十二年》导演史蒂夫?麦奎因(Steve McQueen)在登台领奖时说:我有点吓到了。然后他微微耸肩,引用片中福音歌曲的歌词,说了句“翻涌吧,约旦河,翻涌吧”("Roll, Jordan, roll")。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

2018年特里萨梅(Theresa May)会继续担任英国首相吗
As for China, lack or stopped development represents the biggest risk for this country. So it is essential that we maintain steady medium-high growth of our economy and that in itself is China’s contribution to global stability.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

8月12日,港口城市天津的一座非法储存危险化学品的仓库发生一连串爆炸,导致173人死亡,数百人受伤,造成的破坏景象仿佛末日来袭。此次爆炸事件提出了有关中国在快速工业化进程中安全监管松懈的严肃问题。
用这个背带背孩子更加方便舒适。
我们也不希望打贸易战。我们坚持人民币汇率形成机制的改革,保持了人民币汇率在合理均衡水平上的基本稳定。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

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Going into the debate at Lynn University in Boca Raton, Florida, Obama had an inbuilt advantage on foreign policy and security. As president, with access to daily briefings by intelligence analysts, diplomats and generals, he is better briefed and it showed as he dominated Romney in the first half of the debate.

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